Yes. Flushing and rash are the most common side effects of niacin, a preferred treatment for high triglycerides, a type of artery-clogging fat. Steps that can reduce those effects include taking aspirin or ibuprofen (Advil, Motrin IB, and generic) 30 to 60 minutes before the niacin; taking niacin with a snack or meal; avoiding hot beverages, baths, or showers within an hour or so of your dose; taking your dose before bedtime; and using the lowest effective dose.