Think twice about your ticker if you regularly pop painkillers such as ibuprofen (Advil and generic) or celecoxib (Celebrex). A major study published this week in the British Medical Journal confirms previous concerns that long-term use of the drugs can lead to heart attacks and strokes.

While all of these painkillers, known as non-steroidal anti-inflammatory drugs (NSAIDs), can be dangerous for the heart, some pose less of a risk than others, according to the study, which looked at 31 trials that included more than 116,000 people. Naproxen (Aleve, Naprosyn, and generic) appeared to pose the lowest risk of a heart attack, while diclofenac (Voltaren and generic) had the highest risk of cardiovascular death among the NSAIDs currently available in the U.S.